Open AccessEfficacy and safety of steroid therapy in COVID-19: A rapid systematic review and Meta-analysis
Author(s) -
Phulen Sarma,
Anusuya Bhattacharyya,
Hardeep Kaur,
Manisha Prajapat,
Ajay Prakash,
Subodh Kumar,
Seema Bansal,
Richard Kirubakaran,
Dibbanti Harikrishna Reddy,
Gaurav Muktesh,
Kanica Kaushal,
Saurabh Sharma,
Nishant Shekhar,
Pramod Avti,
Prasad Thota,
Bikash Medhi
Publication year - 2020
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/ijp.ijp_1146_20
Subject(s) - medicine , mechanical ventilation , observational study , intensive care unit , meta analysis , population , randomized controlled trial , context (archaeology) , relative risk , intensive care medicine , confidence interval , biology , paleontology , environmental health
Although the use of steroids in the management of COVID-19 has been addressed by a few systematic review and meta-analysis, however, they also used data from "SARS-CoV" and "MERS-CoV." Again, most of these studies addressed only one severity category of patients or addressed only one efficacy endpoint (mortality). In this context, we conducted this meta-analysis to evaluate the efficacy and safety of steroid therapy among all severity categories of patients with COVID-19 (mild to moderate and severe to critical category) in terms of "mortality," "requirement of mechanical ventilation," "requirement of ICU" and clinical cure parameters.