Open AccessSympathetic ophthalmia related to conjunctival invasive squamous-cell carcinoma
Author(s) -
Inês Leal,
David Cordeiro Sousa,
Claudia Regina de Oliveira Magalhães da Silva Loureiro,
Ana Glória Fonseca
Publication year - 2017
Publication title -
indian journal of ophthalmology/indian journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 51
eISSN - 1998-3689
pISSN - 0301-4738
DOI - 10.4103/ijo.ijo_983_16
Subject(s) - medicine , sympathetic ophthalmia , immunosuppression , basal cell , differential diagnosis , eye neoplasm , dermatology , carcinoma , surgery , ophthalmology , pathology , uveitis
Sympathetic ophthalmia (SO) is a rare, diffuse, bilateral, and granulomatous nonnecrotizing panuveitis that may follow intraocular penetrating trauma. Our aim is to report a rare case of SO following orbital exenteration. Orbital exenteration was performed on a 48-year-old african female due to conjunctival keratinizing squamous cell carcinoma with intraocular involvement of the left eye. Five days after the uneventful procedure, the patient presented signs and symptoms compatible with SO. Key differential diagnoses were excluded, and prompt and aggressive immunosuppression was started with a favourable but slow clinical response. This case highlights the fact that SO can also be induced by a neoplasm with intraocular invasion or by aggressive nonpenetrating surgery. While the underlying pathogenesis of SO is still not fully elucidated, we hereby contribute with a novel potential mechanism leading to its development.