Open AccessCase report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies
Author(s) -
Subramaniam Rajesh Bharathi Devi,
Karunakaran Coral,
Karthikeyan Gayathree,
Muthuvel Bharathselvi,
Sivasankar Shanmuganathan,
Jyotirmoy Biswas,
Pukhraj Rishi,
Sundaram Natarajan,
SS Badrinath,
Narayanasamy Angayarkanni
Publication year - 2019
Publication title -
indian journal of ophthalmology/indian journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 51
eISSN - 1998-3689
pISSN - 0301-4738
DOI - 10.4103/ijo.ijo_400_19
Subject(s) - medicine , diabetic retinopathy , pedf , adiponectin , paraoxonase , retinal , diabetes mellitus , ophthalmology , angiogenesis , retinopathy , retina , pon1 , proliferative vitreoretinopathy , endocrinology , retinal detachment , gene , insulin resistance , biochemistry , oxidative stress , biology , neuroscience , genotype
We were intrigued to analyze donor eyes of two individuals without retinopathy even after 40 years of type 2 diabetes mellitus. Targeted molecular factors associated with angiogenesis and the key antioxidant enzymes in retinal tissue were analyzed. Accordingly PEDF, Adiponectin and Paraoxonase 2 showed augmented mRNA expression in both the retina with no significant change in VEGF expression. Vitreous showed increased PEDF protein in donor 1 and Adiponectin in donor 2 with no change in VEGF protein. This study highlights the profile of specific molecular factors that contribute to the non-development of diabetic retinopathy changes in these individuals.