Open AccessTroubleshooting for F-18 fluorocholine synthesis: An institutional experience
Author(s) -
Rakhee Vatsa,
Raman Kumar Joshi,
Jaya Shukla,
Bhagwant Rai Mittal
Publication year - 2018
Publication title -
indian journal of nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 13
eISSN - 0972-3919
pISSN - 0974-0244
DOI - 10.4103/ijnm.ijnm_85_18
Subject(s) - troubleshooting , medicine , prostate cancer , choline , cancer , engineering , reliability engineering
Choline is a natural substrate for phospholipid synthesis. F-18 labeled fluorocholine nowadays is routinely used for imaging brain tumors, parathyroid adenoma, and prostate cancer. It is synthesized through nucleophilic substitution reaction using dibromomethane and N, N-dimethylaminoethanol as primary and secondary precursors, respectively. However, sometimes, failures are encountered in F-18 fluorocholine production. Few problems and troubleshooting during synthesis are discussed here.