Open AccessNonspecific uptake of 68Ga-prostate-specific membrane antigen in diseases other than prostate malignancy on positron emission tomography/computed tomography imaging: A pictorial assay and review of literature
Author(s) -
Dharmender Malik,
Apurva Sood,
Bhagwant Rai Mittal,
Harmandeep Singh,
Rajender Kumar Basher,
Jaya Shukla,
Anish Bhattacharya,
Shrawan Kumar Singh
Publication year - 2018
Publication title -
indian journal of nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 13
eISSN - 0972-3919
pISSN - 0974-0244
DOI - 10.4103/ijnm.ijnm_81_18
Subject(s) - medicine , prostate cancer , positron emission tomography , glutamate carboxypeptidase ii , positron emission tomography computed tomography , malignancy , prostate , nuclear medicine , radiology , tomography , cancer , pathology
68 Ga-labeled prostate-specific membrane antigen (PSMA) ligand positron emission tomography/computed tomography imaging (PET/CT) is a rapidly evolving imaging modality for prostate cancer. Many studies have proved its superiority in staging, restaging, and detecting the recurrent prostate cancer. However, case reports describing the incidental tracer uptake in benign and nonprostatic malignancies are also reported in the literature, thus questioning the specificity of the tracer. This pictorial assay illustrates the nonspecific tracer uptake encountered during PSMA PET/CT imaging, knowledge of which can increase the confidence of interpreting physicians and may also open a new path for peptide receptor radionuclide therapy in nonprostatic malignancies.