Open AccessChemoinformatic study and In vitro bioevaluation of Tc-99m-labeled N-acetyl neuraminic acid in C6 glioma cells: Potential role as a radionuclide imaging probe
Author(s) -
Ravi Kumar,
Radhika R. Jaswal,
Avneet Saini,
D. K. Dhawan,
Vijayta Dani Chadha
Publication year - 2021
Publication title -
indian journal of nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 13
eISSN - 0972-3919
pISSN - 0974-0244
DOI - 10.4103/ijnm.ijnm_5_21
Subject(s) - neuraminic acid , in vivo , conformational isomerism , in vitro , cytotoxicity , medicine , glioma , sialic acid , nuclear medicine , cancer research , chemistry , biochemistry , biology , organic chemistry , molecule , microbiology and biotechnology
To date, the use of sialic acid that are reported to be elevated during malignancy has been largely unexplored for tumor imaging. The purpose of the present study was to study the modeled stable conformers of n-acetyl neuraminic acid (Neu5Ac) and its radiolabeled conjugate (Tc-99m-Neu5Ac) through computational chemistry approach and its in-vitro bioevaluation in rat C6 cell lines.