Open AccessTumefactive demyelination versus primary central nervous system lymphoma on 18F-fluorodeoxyglucose positron emission tomography magnetic resonance imaging: A twist in the tale
Author(s) -
Shamick Biswas,
Chandagaraj,
Sandhya Mangalore,
Arun Kumar Gupta
Publication year - 2019
Publication title -
indian journal of nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 13
eISSN - 0972-3919
pISSN - 0974-0244
DOI - 10.4103/ijnm.ijnm_31_19
Subject(s) - medicine , magnetic resonance imaging , positron emission tomography , nuclear medicine , twist , brain positron emission tomography , positron emission , radiology , nuclear magnetic resonance , preclinical imaging , physics , geometry , mathematics , microbiology and biotechnology , biology , in vivo
Demyelinating lesions of the central nervous system (CNS) are classically known to be hypometabolic on 18 F-Flurodeoxyglucose Positron Emission Tomography ( 18 F-FDG PET). However, demyelinating lesions may show increased tracer uptake on 18 F-FDG PET and can radiologically mimic neoplasm. Delayed tracer uptake on FDG PET is one of the diagnostic hallmarks of primary CNS lymphoma (PCNSL). Here, we present two cases in which the brain lesions showed increased FDG uptake on delayed integrated PET Magnetic Resonance Imaging (MRI), which were pathologically proven as CNS demyelination. Such demyelinating lesions may also act as "sentinel lesions" and potential harbinger of PCNSL on follow-up.