Open AccessAutomated radiosynthesis, quality control, and biodistribution of Ga-68 pentixafor: First Indian experience
Author(s) -
Ankit Watts,
Surbhi Chutani,
Diksha Arora,
Vasanth Madivanane,
Samiksha Thakur,
Monika Kamboj,
Baljinder Singh
Publication year - 2021
Publication title -
indian journal of nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 13
eISSN - 0972-3919
pISSN - 0974-0244
DOI - 10.4103/ijnm.ijnm_216_20
Subject(s) - radiosynthesis , biodistribution , nuclear medicine , medicine , positron emission tomography , pet imaging , pathology , radiochemistry , in vitro , biology , chemistry , biochemistry
Chemokine receptor CXCR4 is overexpressed in more than 27 different human tumors that make it a promising target in oncology. Ga-68 Pentixafor is the most promising positron emission tomography tracer for imaging CXCR4 receptors; hence, the present study was carried out to optimize the radiosynthesis of Ga-68-Pentixafor using fully automated method and the quality control (QC) checks were performed before being used as a clinical product. We also studied the normal biodistribution pattern of Ga-68-pentixafor intended for the use in variety of malignancies.