Open AccessGraves' ophthalmopathy on68Ga-DOTANOC positron emission tomography/computed tomography
Author(s) -
Saurabh Arora,
Nishikant Damle,
Rachna Meel,
Kusum Lata,
Nikhil Tandon,
Sanjay Sharma,
Chandrasekhar Bal
Publication year - 2019
Publication title -
indian journal of nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 13
eISSN - 0972-3919
pISSN - 0974-0244
DOI - 10.4103/ijnm.ijnm_147_19
Subject(s) - medicine , positron emission tomography , somatostatin receptor , positron emission tomography computed tomography , somatostatin , tomography , inflammation , positron emission , nuclear medicine , computed tomography , regimen , radiology
Graves' ophthalmopathy (GO) involves autoimmune activation of fibroblasts, resulting in chronic inflammatory reaction. Somatostatin receptors are expressed in the cells associated with chronic inflammation. We hereby present patients with active GO, with delayed response to the standard treatment regimen, in whom 68 Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) was planned to evaluate the orbital inflammation. 68 Ga-DOTANOC PET/CT shows no physiological orbital muscle uptake. It can provide information which may possibly of utility in response assessment and also screening patients who fail to respond to conventional treatment, for newer therapies such as long-acting somatostatin analogs.