Open AccessMolecular imaging to the surgeons rescue: Gallium-68 DOTA-exendin-4 positron emission tomography-computed tomography in pre-operative localization of insulinomas
Author(s) -
U N Pallavi,
Vindhya Malasani,
Ishita Sen,
Parul Thakral,
Sugandha Dureja,
Vineet Pant,
Vinay Gaikwad,
Arvind Sabharwal
Publication year - 2019
Publication title -
indian journal of nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 13
eISSN - 0972-3919
pISSN - 0974-0244
DOI - 10.4103/ijnm.ijnm_119_18
Subject(s) - insulinoma , medicine , pet ct , positron emission tomography , dota , nuclear medicine , hyperinsulinemic hypoglycemia , radiology , computed tomography , pancreas , hypoglycemia , insulin , in vivo , microbiology and biotechnology , biology
Insulinoma is an islet-cell neoplasm that secretes insulin. It is usually localized to the pancreas and is often the most common cause of endogenous hyperinsulinemic hypoglycaemia in non-diabetic adult patients. Surgical excision with a curative intent is the standard modality of treatment, and it requires precise localization of tumor tissue. Ga-68 DOTA-exendin-4 PET/CT scan is a clinically reasonable and sensitive scan for the identification of insulinoma. The aim of this prospective cohort study was to determine the overall accuracy of Ga-68 DOTA-exendin-4 PET/CT scan in the detection of insulinoma.