Open AccessInfluence of CYP3A5 and ABCB1 polymorphism on tacrolimus drug dosing in South Indian renal allograft recipients
Author(s) -
M Edwin Fernando,
Manokaran Sellappan,
Narayan Prasad,
S Sujit,
K Thirumalvalavan
Publication year - 2019
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/ijn.ijn_97_18
Subject(s) - tacrolimus , medicine , cyp3a5 , gastroenterology , population , genotype , incidence (geometry) , dosing , pharmacology , transplantation , biology , biochemistry , environmental health , gene , physics , optics
Tacrolimus blood levels are influenced by polymorphisms involving Cytochrome 3A subfamily (CYP3A5) and P-Glycoprotein (ABCB-1) genes. However, their role in transplant outcomes was less studied in South Indian population. We studied the prevalence and impact of these polymorphisms in renal transplant recipients from South India.