Open AccessRare cause of hyperkalemia in the newborn period: Report of two cases of pseudohypoaldosteronism Type 1
Author(s) -
Manipriya Ravindran,
B Umamaheswari,
Annapoorna Prakash,
N Binu
Publication year - 2018
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/ijn.ijn_258_14
Subject(s) - hyperkalemia , pseudohypoaldosteronism , medicine , hyponatremia , metabolic acidosis , aldosterone , mineralocorticoid , acidosis , wasting , pediatrics , endocrinology , plasma renin activity , renin–angiotensin system , blood pressure
Pseudohypoaldosteronism (PHA) Type 1 is characterized by mineralocorticoid resistance, manifesting as neonatal salt wasting, hypotension, hyperkalemia, hyponatremia, and metabolic acidosis in spite of elevated aldosterone levels and plasma renin activity. It is important to differentiate children with systemic PHA from renal PHA, as these children are likely to decompensate even with mild symptoms. Here, we report two neonates with PHA that presented to us with multiorgan involvement.