Open AccessCatastrophic antiphospholipid syndrome in immune thrombocytopenic purpura – Beyond tenuous concomitance!
Author(s) -
Arun B. Joshi,
Vivek Sood,
Satish Mendonca,
Pavitra Manu Dogra,
G Batta,
Rohit Kumar Tiwari,
Uday Yanamandra
Publication year - 2020
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/ijn.ijn_188_19
Subject(s) - medicine , thrombocytopenic purpura , thrombotic thrombocytopenic purpura , antiphospholipid syndrome , purpura (gastropod) , immune system , pediatrics , immunology , antibody , platelet , ecology , biology
Significance of antiphospholipid antibodies in immune thrombocytopenic purpura is debatable and pose a diagnostic and therapeutic dilemma. Catastrophic antiphospholipid syndrome is a rare life-threatening entity, occurring in patients with antiphospholipid syndrome, usually after a triggering event. We describe an adult lady of chronic immune thrombocytopenic purpura (in remission) with antiphospholipid antibodies, who presented with rapidly progressive renal failure and had primary antiphospholipid syndrome nephropathy. The index manuscript titled exemplifies the fact that although the presence of APLA in ITP is known, however, management in the absence of clinical event remains debatable and may carry a future risk of thrombotic event/s mandating close monitoring with a high index of suspicion.