Open AccessCedrus deodara: In vitro antileishmanial efficacy & immumomodulatory activity
Author(s) -
Shyam Narayan,
C.P. Thakur,
Shiv Bahadur,
Meenakshi Thakur,
Shashi Pandey,
Ajit Kumar Thakur,
Dipendra Kumar Mitra,
Pulok K. Mukherjee
Publication year - 2017
Publication title -
indian journal of medical research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_959_16
Subject(s) - linalool , ethyl acetate , visceral leishmaniasis , bioassay , leishmaniasis , traditional medicine , pharmacology , chemistry , amastigote , chloroform , leishmania , leishmania major , in vitro , chromatography , medicine , biology , immunology , biochemistry , parasite hosting , essential oil , world wide web , computer science , genetics
The existing antileishmanial drugs for complete cure of visceral leishmaniasis (kala-azar) are limited. The available drugs are either toxic or less effective leading to disease relapse or conversion to post-kala-azar dermal leishmaniasis. Several herbal extracts have been shown to have antileishmanial activity, but a herbal drug may not always be safe. In the present study, the extract of Cedrus deodara leaves has been standardized and tested for immunomodulatory antileishmanial activities.