Open AccessSynergism in dual functionality of cryptdin-2 in conjunction with antibiotics against Salmonella
Author(s) -
Anumeha Singh,
Vijay Prabha,
Praveen Rishi
Publication year - 2016
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_850_14
Subject(s) - salmonella , in vivo , antibiotics , ciprofloxacin , chemistry , context (archaeology) , pharmacology , microbiology and biotechnology , biology , bacteria , paleontology , genetics
The emergence of multidrug-resistant Salmonella over the last two decades poses a major health risk. In this context, antimicrobial peptides have found a strategic place in the therapeutic armamentarium. Previously, we found that cryptdin-2 has the potential to augment the activity of conventional second- and third-generation anti-Salmonella antibiotics as evident by in vitro assays. In continuation to this, the present study was designed to evaluate the in vivo synergistic effects, if any, of cryptdin-2 in combination with ciprofloxacin and ceftriaxone against murine salmonellosis.