Open AccessJapanese encephalitis virus-induced neuropathology in mouse model infected through the conjunctival route
Author(s) -
M. S. Sethi,
Tareni Das,
Neelam Tomar,
Jeny K John,
Z. B. Dubal,
Kaushal Kishor Rajak,
Rajendra Singh,
G. Saikumar
Publication year - 2019
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_2078_17
Subject(s) - gliosis , pathology , virus , olfactory bulb , japanese encephalitis , histopathology , viral encephalitis , biology , virology , neuropathology , encephalitis , cerebrum , spleen , medicine , central nervous system , immunology , disease , neuroscience
Mouse is a preferred animal model for studying pathogenesis of Japanese encephalitis virus (JEV) infections, and different routes of inoculation have been tried. Some neurotropic viruses can reach the brain following infection through ocular route. This study was undertaken to establish JEV-induced clinical disease in mouse model through conjunctival route and document the neuropathological effects.