Open AccessThe IRF5 rs2004640 (G/T) polymorphism is not a genetic risk factor for systemic lupus erythematosus in population from south India
Author(s) -
Panneer Devaraju,
Sonal Mehra,
Reena Gulati,
Paul T Antony,
Vikramraj K Jain,
Durga Prasanna Misra,
Vir Singh Negi
Publication year - 2018
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_2025_16
Subject(s) - irf5 , immunology , odds ratio , allele , serology , single nucleotide polymorphism , population , medicine , biology , interferon regulatory factors , genotype , genetics , antibody , gene , immune system , environmental health , innate immune system
Genetic aberrations disrupting toll-like receptor and interferon homeostasis enhance the risk of systemic lupus erythematosus (SLE). Raised serum interferon-alpha (IFN-α) levels in SLE patients have been ascribed to polymorphism (rs2004640 G/T) in interferon regulatory factor 5 (IRF5) gene, resulting in enhanced transcript splicing. A positive association between IRF5 polymorphism and SLE risk has been reported in many populations. This study was aimed to find out frequency of IRF5 rs2004640 G/T polymorphism in patients with SLE and healthy controls and to assess its influence on susceptibility, clinical and serological characteristics of SLE.