Open AccessA descriptive pilot study of mitochondrial mutations & clinical phenotype in fibromyalgia syndrome
Author(s) -
Sumita Danda,
Blessy Thomas,
G Paramasivam,
Raji Thomas,
John Mathew,
Debashish Danda
Publication year - 2019
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1977_16
Subject(s) - mitochondrial dna , biology , mitochondrial myopathy , mitochondrial encephalomyopathy , lactic acidosis , genetics , mutation , myopathy , medicine , melas syndrome , polymerase chain reaction , endocrinology , microbiology and biotechnology , gene
: Fibromyalgia syndrome (FMS) is one of the most common chronic pain conditions of unknown aetiology. Mitochondrial dysfunction has been reported in FMS with some studies reporting the presence of mitochondrial mutation namely A3243G, which also causes mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes. This pilot study was conducted to assess this mutation and also detect large deletions in mitochondrial DNA (mtDNA) in patients with FMS.