Open AccessModelling of cerebral tuberculosis in BALB/c mice using clinical strain from patients with CNS tuberculosis infection
Author(s) -
Aliabbas A. Husain,
Umesh Datta Gupta,
Pushpa Gupta,
Amit R. Nayak,
Nitin H. Chandak,
Hatim F. Daginawla,
Lokendra Singh,
Rajpal S. Kashyap
Publication year - 2017
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1930_15
Subject(s) - medicine , tuberculosis , mycobacterium tuberculosis , cerebrospinal fluid , histopathology , pathogenesis , central nervous system , immunology , disease , lung , pathology
Central nervous system (CNS) infection caused by Mycobacterium tuberculosis (MTB) is the most severe form of extrapulmonary tuberculosis (EPTB) due to a high level of mortality and morbidity. Limited studies are available on CNS-TB animal model development. The present study describes the development of a murine model of CNS-TB using a clinical strain (C3) isolated from the cerebrospinal fluid (CSF) of CNS-TB patients.