Open AccessAssociation of genetic polymorphism of interleukin-17A & interleukin-17F with susceptibility of psoriasis
Author(s) -
Rajinder Kaur,
Arun Rawat,
Sunil Kumar,
Aadil Wani,
Tahseena Akhtar,
Tarun Narang,
Dimple Chopra
Publication year - 2018
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1859_16
Subject(s) - psoriasis , single nucleotide polymorphism , interleukin 17 , immunology , allele , pathogenesis , interleukin , snp , cytokine , medicine , biology , genotype , genetics , gene
Psoriasis is a chronic inflammatory skin disease with unknown aetiology. So far studies have confirmed that interleukins, pro-inflammatory factors and T-cell activation play major role in the development of disease. Interleukin-17 (IL-17) a T helper inflammatory cytokine, was found to be positively correlated with severity of psoriasis. However, the specific mechanism has not been clarified. IL-17A and IL-17F are group members of IL17 family cytokines and found to be located adjacent to one another on the same human chromosome, 6p12. The present study was designed to identify the association between IL-17A and IL-17F gene polymorphism with susceptibility of psoriasis in north Indian population.