Open AccessInfluence of hepatocyte growth factor-transfected bone marrow-derived mesenchymal stem cells towards renal fibrosis in rats
Author(s) -
Min Xie,
Jianxin Wan,
Fengxia Zhang,
Ruifang Zhang,
Ziyu Zhou,
Danyou You
Publication year - 2019
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1527_16
Subject(s) - hepatocyte growth factor , mesenchymal stem cell , transplantation , fibrosis , bone marrow , angiogenesis , pathology , masson's trichrome stain , chemistry , biology , medicine , cancer research , receptor
Hepatocyte growth factor (HGF) produced by endothelial cells, fibroblasts, fat cells and other interstitial cells, can promote angiogenesis, repair damaged tissues and resist fibrosis. Mesenchymal stem cells (MSCs) are located in bone marrow and secrete a variety of cytokines and are often used in the repair and regeneration of damaged tissues. This study was aimed to investigate the influence of HGF-transfected bone marrow-derived MSCs towards renal fibrosis in rats.