Open AccessEffect of anti-inflammatory activity of ranolazine in rat model of inflammation
Author(s) -
R Naveena,
Nayana K. Hashilkar,
Reshma Davangeri,
Suneel Ishwar Majagi
Publication year - 2018
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1504_16
Subject(s) - ranolazine , inflammation , granulation tissue , anti inflammatory , aspirin , carrageenan , medicine , gum acacia , granuloma , pharmacology , haematoxylin , pathology , immunology , staining , chemistry , wound healing , food science
Inflammatory processes are a recognized feature of atherosclerotic lesions. Ranolazine inhibits the inflammatory markers such as C-reactive protein, interleukins-1 and -6 and tumour necrosis factor-alpha. The present study was planned to evaluate the effect of anti-inflammatory activity of ranolazine in acute and sub-acute models of inflammation in rats and compare the same with that of control (gum acacia 1%) and aspirin (standard anti-inflammatory drug).