Open AccessGenetic variations in the Dravidian population of South West coast of India: Implications in designing case-control studies
Author(s) -
Anitha D’Cunha,
Lekha Pandit,
Chaithra Malli
Publication year - 2017
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1435_15
Subject(s) - international hapmap project , endogamy , population , demography , biology , genetic variation , allele frequency , caste , analysis of molecular variance , genetic association , genetics , allele , evolutionary biology , single nucleotide polymorphism , genetic structure , genotype , haplotype , gene , sociology , linguistics , philosophy
Indian data have been largely missing from genome-wide databases that provide information on genetic variations in different populations. This hinders association studies for complex disorders in India. This study was aimed to determine whether the complex genetic structure and endogamy among Indians could potentially influence the design of case-control studies for autoimmune disorders in the south Indian population.