Open AccessA surface antigen of Orientia tsutsugamushi activates human monocyte-derived dendritic cells via nuclear factor-kB & p38 mitogen-activated protein kinase pathways
Author(s) -
RongHwa Jan,
ChiaJung Chen,
YiRen Hong,
YuLi Lin,
LiKuang Chen
Publication year - 2018
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1417_16
Subject(s) - cd80 , cd86 , orientia tsutsugamushi , scrub typhus , biology , cd40 , protein kinase a , p38 mitogen activated protein kinases , microbiology and biotechnology , t cell , immune system , kinase , immunology , cytotoxic t cell , virology , biochemistry , in vitro
Scrub typhus is a chigger-borne disease caused by Orientia tsutsugamushi. The immunological reactions to O. tsutsugamushi infection are not completely understood. In this study, we investigated the response of dendritic cells (DCs) to a major 56-kDa scrub typhus antigen Sta56.