Open AccessUse of succinic & oxalic acid in reducing the dosage of colistin against New Delhi metallo-β-lactamase-1 bacteria
Author(s) -
Ravichandiran Kumar,
Brinda Chandar,
Madasamy Parani
Publication year - 2018
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1407_16
Subject(s) - colistin , succinic acid , oxalic acid , chemistry , antibiotics , citric acid , bacteria , tartaric acid , fumaric acid , malic acid , minimum inhibitory concentration , organic acid , microbiology and biotechnology , biochemistry , biology , genetics
New Delhi metallo-β-lactamase 1 (NDM-1) cleaves the beta-lactam ring, and confers bacterial resistance against most of the beta-lactam antibiotics, except tigecycline and colistin. Among these two antibiotics, colistin is considered toxic, and therefore, its clinical use and dosage need cautious approach. In the present study, six organic acids were screened individually and in combination of two acids for their effectiveness against NDM-1 Escherichia coli and a combination of colistin and oxalic or succinic acid was tested to find out the potential of combination therapy for reducing the dose of toxic colistin.