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Retrospective analysis of colistin-resistant bacteria in a tertiary care centre in India
Author(s) -
Sharmili Sinha,
Suneeta Sahu,
Jyotirmaya Pati,
Banambar Ray,
Saroj Kumar Pattnaik
Publication year - 2019
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1388_17
Subject(s) - colistin , medicine , retrospective cohort study , incidence (geometry) , antibiotics , meningitis , tracheitis , acinetobacter baumannii , mortality rate , pediatrics , pseudomonas aeruginosa , microbiology and biotechnology , biology , bacteria , bronchitis , physics , genetics , optics
The incidence of carbapenem-resistant Enterobacteriaceae has been steadily rising. The morbidity, mortality and financial implications of such patients are significant. We did a retrospective analysis of the case records of 11 patients who had culture report positive for pan drug-resistant (PDR) organisms. There were total 15 isolates of PDR organisms in 11 patients. These were associated with catheter-associated urinary tract infections (7), tracheitis (4), bacteraemia (2), meningitis (1) and soft-tissue infection (1). Average APACHE II score was 23.72 (range 7-36) indicating patients with multiple co-morbidities and organ dysfunction. The average length of hospital stay was 60.72 (25-123) days. The overall mortality rate was 81.81 per cent, while PDR infection-related mortality was 18.18 per cent. Strict implementation of antibiotic stewardship programme is essential to limit use and prevent abuse of colistin.

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