Open AccessInhibitors of Gq signalling down-regulate β-catenin expression & function in human colon cancer cells
Author(s) -
Nasim Forghani,
S. Mahmoud A. Najafi
Publication year - 2021
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1370_19
Subject(s) - heterotrimeric g protein , transfection , microbiology and biotechnology , hek 293 cells , signal transduction , biology , gq alpha subunit , xenopus , hedgehog signaling pathway , catenin , wnt signaling pathway , receptor , g protein , cell culture , biochemistry , genetics , gene
β-catenin signalling plays a key role in maintaining normal cellular physiology, and therefore, its deregulation can lead to many human diseases including cancers. Previously, we have shown that the activation of Gq signalling positively regulates β-catenin by inhibiting glycogen synthase kinase-3 beta and increasing the stability of β-catenin protein, however, these results were mainly based on overexpression experiments in either Xenopus oocytes or HEK293T cells. The present study was undertaken to evaluate the modulation of Gq signalling in human colon cancer cells.