Open AccessStudy of stem cell homing & self-renewal marker gene profile of ex vivo expanded human CD34+ cells manipulated with a mixture of cytokines & stromal cell-derived factor 1
Author(s) -
Jyoti Kode,
Navin Khattry,
Ashish Bakshi,
Vasanti Amrutkar,
Bhausaheb Bagal,
Rohini Karandikar,
Pallavi Rane,
Nobutaka Fujii,
Shubhada V. Chiplunkar
Publication year - 2017
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1319_15
Subject(s) - homing (biology) , stem cell factor , stem cell , progenitor cell , stromal cell , haematopoiesis , ex vivo , biology , cd90 , cd34 , microbiology and biotechnology , flow cytometry , transplantation , stem cell marker , immunology , cancer research , in vivo , medicine , ecology
Next generation transplantation medicine aims to develop stimulating cocktail for increased ex vivo expansion of primitive hematopoietic stem and progenitor cells (HSPC). The present study was done to evaluate the cocktail GF (Thrombopoietin + Stem Cell factor + Flt3-ligand) and homing-defining molecule Stromal cell-derived factor 1 (SDF1) for HSPC ex vivo expansion.