Open AccessProtection against osteoarthritis in experimental animals by nanogold conjugated snake venom protein toxin gold nanoparticle-Naja kaouthia cytotoxin 1
Author(s) -
Antony Gomes,
Partha Saha,
Tanmoy Bhowmik,
Anjan Kumar Dasgupta,
Subir Chandra Dasgupta
Publication year - 2016
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1078_14
Subject(s) - osteoarthritis , deoxypyridinoline , chemistry , cartilage oligomeric matrix protein , histopathology , synovial fluid , cartilage , arthritis , pharmacology , medicine , pathology , biochemistry , anatomy , alkaline phosphatase , alternative medicine , osteocalcin , enzyme
Increased severity of osteoarthritis (OA) and adverse side effects of its treatment led to the search for alternative therapies. It was previously reported that snake venom protein toxin Naja kaouthia cytotoxin 1 (NKCT1) and gold nanoparticle (GNP) individually have potential against excremental arthritis. In this study, we analyzed the protective activity of GNP conjugated protein toxin NKCT1 (GNP-NKCT1) against experimental OA.