Open AccessPerformance of second-trimester maternal biochemistry screening (quadruple test vs. triple test) for trisomy 21: An Indian experience
Author(s) -
Aanchal Sablok,
Akshatha Sharma,
Chanchal Singh Ahmed,
Anita Kaul
Publication year - 2021
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/ijmr.ijmr_1034_19
Subject(s) - triple test , amniocentesis , trisomy , medicine , obstetrics , down syndrome , pregnancy , prenatal diagnosis , population , advanced maternal age , genetic testing , gynecology , fetus , genetics , biology , environmental health , psychiatry
Down syndrome (DS) is one of the most common causes of developmental delay. In India, there is no protocol for prenatal screening of DS. Second-trimester biochemical screening is still being done by triple test. Quadruple test is with better sensitivity and specificity but is not advised routinely. So, the objective of this study was to evaluate the sensitivity and accuracy of the second-trimester screening (quadruple test with genetic sonogram) for trisomy 21 as compared to biochemical testing.