Open AccessEpstein–Barr Virus Infection in Adult Patients with Gastric Cancer in Northeast of Iran
Author(s) -
Sakineh Amoueian,
Armin Attaranzadeh,
Zeinab Gholamimoallem,
Masoud Sadeghi,
Seyed Mahdi Hashemi,
Abolghasem Allahyari
Publication year - 2018
Publication title -
indian journal of medical and paediatric oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.229
H-Index - 22
eISSN - 0975-2129
pISSN - 0971-5851
DOI - 10.4103/ijmpo.ijmpo_132_17
Subject(s) - medicine , virus , epstein–barr virus , incidence (geometry) , negativity effect , polymerase chain reaction , cancer , gastroenterology , gastric adenocarcinoma , epstein–barr virus infection , immunology , adenocarcinoma , gene , biology , psychology , social psychology , biochemistry , physics , optics
Background: Epstein–Barr virus (EBV) is a DNA virus from human herpes virus that associates with many of the human cancers including gastric cancer (GC). Aims: The aim of the present study was to report infection of EBV in adult patients with GC in Northeast of Iran and the correlation between a number of clinicopathology factors with EBV status. Materials and Methods: In a case–control study in 2016, 56 GC patients and 56 controls were selected for the analysis. All patients had gastric adenocarcinoma untreated patients with age >18 years. EBV status detected by the polymerase chain reaction method. Results: Out of 56 GC patients, 35 (62.5%) were EBV positivity and out of 56 controls 3 (5.4%) were EBV positivity (P 0.05). Furthermore, the progression-free survival rate for the patients with EBV negativity was 95.2% compared with 82.9% for EBV positivity (P = 0.174). Conclusions: This study reported a very high prevalence of EBV-associated GC in the Northeast of Iran compared with other areas of the World and showed a significant correlation between EBV infection and incidence of GC.