Open AccessMolecular profiling of follicular variant of papillary thyroid cancer reveals low-risk noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A paradigm shift to reduce aggressive treatment of indolent tumors
Author(s) -
Nelson George,
Amit Agarwal,
Niraj Kumari,
Sarita Agarwal,
Narendra Krisnani,
Sushil K. Gupta
Publication year - 2018
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/ijem.ijem_86_18
Subject(s) - thyroid neoplasm , medicine , neuroblastoma ras viral oncogene homolog , pathology , thyroid carcinoma , papillary thyroid cancer , thyroid cancer , thyroid , lymphovascular invasion , sodium iodide symporter , cancer research , metastasis , cancer , biology , colorectal cancer , symporter , gene , kras , biochemistry , transporter
Encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) has been reclassified into noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and invasive EFVPTC. NIFTP is considered a low-risk neoplasm. Therefore, follicular variant of papillary thyroid cancer (FVPTC) presently has two distinct histopathological subtypes - invasive EFVPTC and infiltrative/diffuse FVPTC. Molecular characteristics of these groups remain unclear.