Open AccessRelation of bone mineral density with homocysteine and cathepsin K levels in postmenopausal women
Author(s) -
Madhukar Mittal,
Rajeev Verma,
Arvind Mishra,
Ajay Singh,
Vivek Kumar,
Kamal Kumar Sawlani,
Mohammad Kaleem Ahmad,
Pratishtha Mishra,
Rishika Gaur
Publication year - 2018
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/ijem.ijem_575_17
Subject(s) - medicine , bone mineral , postmenopausal women , homocysteine , cathepsin k , endocrinology , osteoporosis , receptor , osteoclast
Homocysteine (HCY) interferes with collagen cross-linking in bones and stimulates osteoclast activity. The activated osteoclasts secrete cathepsin K (CathK), a cysteine protease, in eminent quantity during bone resorption. Hyperhomocysteinemia may effect bone mineral density (BMD) through CathK. We, therefore, examined the relation between HCY and BMD along with CathK, 25-hydroxyvit-D (25[OH]D), intact parathyroid hormone (iPTH), and Vitamin B12.