Open AccessHypothyroidism and depression: Are cytokines the link?
Author(s) -
Parimal Tayde,
Nikhil M Bhagwat,
Pragya Sharma,
Bharat K. Sharma,
Pradip P Dalwadi,
Ashutosh Sonawane,
Alka A Subramanyam,
Manoj Chadha,
Premlata K Varthakavi
Publication year - 2017
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/ijem.ijem_265_17
Subject(s) - levothyroxine , depression (economics) , medicine , montgomery–åsberg depression rating scale , quality of life (healthcare) , tumor necrosis factor alpha , proinflammatory cytokine , rating scale , interleukin 6 , hormone , gastroenterology , endocrinology , major depressive disorder , inflammation , psychology , developmental psychology , nursing , amygdala , economics , macroeconomics
Primary hypothyroidism has been thought of as an inflammatory condition characterized by raised levels of cytokines such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Depression is also well known to occur in hypothyroidism. Depression is also characterized by elevated inflammatory cytokines. We planned to study whether cytokines play an important part in linking these two conditions.