Open AccessOLR1 gene polymorphism and oxidized LDL levels in metabolic syndrome in Indian population
Author(s) -
Elvia Jamatia,
Pramod Lali,
B. C. Koner,
DK Dhanwal,
Muhammad Masroor,
Kritika Krishnamurthy,
Aditi Singh
Publication year - 2018
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/ijem.ijem_112_18
Subject(s) - medicine , metabolic syndrome , polymorphism (computer science) , genetics , gene , endocrinology , genotype , obesity , biology
Metabolic syndrome (MetS) is associated with abnormal lipid profile and high cardiovascular risk. There is an increased prevalence of coronary artery disease and Type 2 Diabetes Mellitus in India. Oxidized Low Density Lipoprotein Receptor 1(OLR1), a cell surface endocytosis receptor recognize, internalize and degrade oxidized LDL (oxLDL) in vascular endothelium and plays a role in the pathogenesis of atherosclerosis. The aim was to explore the association of OLR1 gene polymorphism and measure the serum levels of ox-LDL in patients with MetS in Indian population.