Open AccessEpidermolysis bullosa acquisita and anti-p200 pemphigoid as major subepidermal autoimmune bullous diseases diagnosed by floor binding on indirect immunofluorescence microscopy using human salt-split skin
Author(s) -
Nupur Goyal,
Raghavendra Rao,
Shrutakirthi D Shenoi,
Sathish Pai,
Pramod Kumar,
B.S. Bhogal,
Enno Schmidt,
Detlef Zillikens
Publication year - 2017
Publication title -
indian journal of dermatology, venereology, and leprology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/ijdvl.ijdvl_678_16
Subject(s) - epidermolysis bullosa acquisita , bullous pemphigoid , medicine , immunofluorescence , pemphigoid , epidermolysis bullosa , pathology , dermatology , cicatricial pemphigoid , immunoelectron microscopy , direct fluorescent antibody , autoimmune disease , antigen , antibody , immunology , immunohistochemistry , disease
Subepidermal autoimmune bullous diseases are a diverse group of diseases with overlapping clinical and immunopathological features. Indirect immunofluorescence microscopy on artificially split skin helps to classify these conditions into those with staining on the epidermal side of the split ("roof-binding") and those with staining on the dermal side ("floor-binding"). Epidermolysis bullosa acquisita is the prototype of "floor-binding" subepidermal autoimmune bullous diseases. However, not all floor-binding sera are associated with epidermolysis bullosa acquisita.