Open AccessSuccessful treatment of Rosai–Dorfman disease using in situ photoimmunotherapy
Author(s) -
Meng Li,
Lei Shi,
Min Luo,
Jia Chen,
Bo Wang,
Fuhe Zhang,
Uma Keyal,
Anil Bhatta,
Wei R. Chen,
Xiuli Wang
Publication year - 2017
Publication title -
indian journal of dermatology, venereology, and leprology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/ijdvl.ijdvl_356_16
Subject(s) - imiquimod , medicine , rosai–dorfman disease , surgery , dermatology , disease , pathology
Rosai-Dorfman disease is difficult to cure. In situ photoimmunotherapy combines local photothermal therapy with immunoadjuvant. In the present case report, a 39-year-old Chinese man with Rosai-Dorfman disease lesions below the left nostril and left preauricular region was treated with in situ photoimmunotherapy. The patient was treated with daily application of topical imiquimod (5%) and laser irradiations every 2 weeks for 8 weeks. After three cycles of treatment, the lesions improved markedly without adverse effects. Our results showed that in situ photoimmunotherapy can be used as an effective treatment for Rosai-Dorfman disease.