Successful treatment of Rosai–Dorfman disease using in situ photoimmunotherapy | Zendy

Meng Li | Zendy; Lei Shi | Zendy; Min Luo | Zendy; Jia Chen | Zendy; Bo Wang | Zendy; Fuhe Zhang | Zendy; Uma Keyal | Zendy; Anil Kumar Bhatta | Zendy; Wei R. Chen | Zendy; Xiuli Wang | Zendy

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Successful treatment of Rosai–Dorfman disease using in situ photoimmunotherapy

Author(s) -

Meng Li,

Lei Shi,

Min Luo,

Jia Chen,

Bo Wang,

Fuhe Zhang,

Uma Keyal,

Anil Kumar Bhatta,

Wei R. Chen,

Xiuli Wang

Publication year - 2017

Publication title -

indian journal of dermatology venereology and leprology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.514

H-Index - 45

eISSN - 0973-3922

pISSN - 0378-6323

DOI - 10.4103/ijdvl.ijdvl_356_16

Subject(s) - imiquimod , medicine , rosai–dorfman disease , surgery , dermatology , disease , pathology

Rosai-Dorfman disease is difficult to cure. In situ photoimmunotherapy combines local photothermal therapy with immunoadjuvant. In the present case report, a 39-year-old Chinese man with Rosai-Dorfman disease lesions below the left nostril and left preauricular region was treated with in situ photoimmunotherapy. The patient was treated with daily application of topical imiquimod (5%) and laser irradiations every 2 weeks for 8 weeks. After three cycles of treatment, the lesions improved markedly without adverse effects. Our results showed that in situ photoimmunotherapy can be used as an effective treatment for Rosai-Dorfman disease.

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