Open AccessMethotrexate iontophoresis versus coal tar ointment in palmoplantar psoriasis: A pilot study
Author(s) -
K Haseena,
Sandhya George,
Najeeba Riyaz,
Sarita Sasidharanpillai,
Paul V Puthussery
Publication year - 2017
Publication title -
indian journal of dermatology, venereology, and leprology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/ijdvl.ijdvl_185_16
Subject(s) - iontophoresis , psoriasis , medicine , methotrexate , dermatology , erythema , drug , surgery , pharmacology , radiology
Palmoplantar psoriasis is often disabling and refractory to conventional therapy. Systemic drugs are indicated in its severe form, but side effects are a concern with their use. Methotrexate is one such systemic drug which is effective and cheap. To reduce systemic toxicity, methotrexate has been tried topically but results have been inconsistent due to poor drug penetration into the skin by passive diffusion. Iontophoresis may enhance its absorption and efficacy.