Open AccessExpression of the receptor for advanced glycation end products in acquired reactive perforating collagenosis
Author(s) -
Gülşen Akoğlu,
Nuran Süngü,
Eda Karaismailoğlu,
Akın Aktaş
Publication year - 2017
Publication title -
indian journal of dermatology, venereology, and leprology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/ijdvl.ijdvl_113_16
Subject(s) - rage (emotion) , glycation , pathogenesis , medicine , pathology , endothelium , receptor , skin biopsy , immunohistochemistry , biopsy , diabetes mellitus , inflammation , immunology , endocrinology , biology , neuroscience
Acquired reactive perforating collagenosis (ARPC) is a rare skin disorder characterized by transepidermal elimination of dermal collagen. There is little data regarding the pathogenesis of ARPC. The receptor for advanced glycation end products (RAGE) is a multiligand transmembrane receptor that plays an important role in inflammatory responses and may be involved in the pathogenesis of ARPC.