Open AccessProtective effects of glutamine on human melanocyte oxidative stress model
Author(s) -
Keyu Wang,
Liya Jiang,
Zhen Guo,
Yulong Kong,
Jianhua Liang,
Yi Wang
Publication year - 2018
Publication title -
indian journal of dermatology venereology and leprology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/ijdvl.ijdvl_106_17
Subject(s) - oxidative stress , malondialdehyde , superoxide dismutase , glutamine , heme oxygenase , reactive oxygen species , glutathione , melanocyte , chemistry , biochemistry , biology , heme , cancer research , amino acid , enzyme , melanoma
Vitiligo is a disorder caused by the loss of the melanocyte activity on melanin pigment generation. Studies show that oxidative-stress induced apoptosis in melanocytes is closely related to the pathogenesis of vitiligo. Glutamine is a well known antioxidant with anti-apoptotic effects, and is used in a variety of diseases. However, it is unclear whether glutamine has an antioxidant or anti-apoptotic effect on melanocytes.
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