Open AccessPlatelet-rich fibrin or platelet-rich plasma – which one is better? an opinion
Author(s) -
Shweta Bansal,
Arun Garg,
Richa Khurana,
Parul Chhabra
Publication year - 2017
Publication title -
indian journal of dental sciences
Language(s) - English
Resource type - Journals
eISSN - 2231-2293
pISSN - 0976-4003
DOI - 10.4103/ijds.ijds_55_17
Subject(s) - fibrin , platelet rich fibrin , platelet , thrombin , platelet rich plasma , chemistry , microbiology and biotechnology , centrifugation , extracellular , regeneration (biology) , biomaterial , platelet concentrate , biomedical engineering , biochemistry , biophysics , immunology , medicine , biology
The healing of hard and soft tissue in mediated by a wide range of intracellular and extracellular events that are regulated by signaling proteins. Platelets can play a crucial role in periodontal regeneration as they are the reservoirs of growth factors and cytokines which are the key factors for regeneration of bone and maturation of soft tissue. Platelet-rich plasma (PRP) is first generation platelet concentrate. However, the short duration of cytokine release and its poor mechanical properties have resulted in search of new material. Platelet-rich fibrin (PRF) is a natural fibrin-based biomaterial prepared from an anticoagulant-free blood harvest without any artificial biochemical modification (no bovine thrombin is required) that allows obtaining fibrin membranes enriched with platelets and growth factors. The slow polymerization during centrifugation, fibrin-based structure, ease of preparation, minimal expense makes PRF somewhat superior in some aspect to PRP