Effectiveness of curcumin mouthwash on radiation-induced oral mucositis among head and neck cancer patients: A triple-blind, pilot randomised controlled trial | Zendy

Gaurav Sharma | Zendy; Swikant Shah | Zendy; Hemamalini Rath | Zendy; Surendranath Senapati | Zendy; Ekagrata Mishra | Zendy

Open Access

Effectiveness of curcumin mouthwash on radiation-induced oral mucositis among head and neck cancer patients: A triple-blind, pilot randomised controlled trial

Author(s) -

Gaurav Sharma,

Swikant Shah,

Hemamalini Rath,

Surendranath Senapati,

Ekagrata Mishra

Publication year - 2020

Publication title -

indian journal of dental research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.277

H-Index - 43

eISSN - 1998-3603

pISSN - 0970-9290

DOI - 10.4103/ijdr.ijdr_822_18

Subject(s) - mucositis , medicine , head and neck cancer , curcumin , head and neck , randomized controlled trial , radiation therapy , dentistry , surgery , pharmacology

Radiation-induced oral mucositis (RIOM) is considered the most severe non-haematological complication affecting almost every head and neck cancer patient during the course of radiotherapy (RT). Curcumin, a herbal agent present in Indian spice 'Turmeric' has anti-inflammatory, immunomodulation and wound healing properties. The objective of this pilot randomised controlled clinical trial was to compare the effectiveness and safety of 0.1% curcumin (freshly prepared using nanoparticles) and 0.15% benzydamine mouthwash on RIOM among 74 head and neck cancer patients scheduled to receive RT.

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