Open AccessImmunohistochemical expression of polo-like kinase 1 in oral squamous cell carcinoma and oral submucous fibrosis
Author(s) -
Kavitha Vittal,
Sathasivasubramanian Sankara Pandian,
Leena Dennis Joseph,
Shilpa Germaine Raj
Publication year - 2018
Publication title -
indian journal of dental research/indian journal of dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 43
eISSN - 1998-3603
pISSN - 0970-9290
DOI - 10.4103/ijdr.ijdr_59_17
Subject(s) - oral submucous fibrosis , immunohistochemistry , staining , pathology , medicine , plk1 , carcinoma , cancer , cell cycle
Polo-like kinase 1 (PLK1) is a critical molecule in the proliferation of several human cancers. Overexpression of PLK1 has been correlated with cancer cell proliferation and lower overall survival rates. Although PLK1 has been studied in various tumors, information regarding its expression in oral cancer and precancer is limited. Aims: This study is aimed at evaluating the expression of PLK1 in a potentially malignant and malignant disorder of the oral cavity, namely, oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC), respectively, using the immunohistochemistry technique. It also intended to evaluate the association of the various histological grades of OSCC with the intensity of PLK1 expression.