Open AccessAutoimmunity and periodontal disease: Arguing a possible correlation
Author(s) -
Giovanna Rosa Degasperi,
Marina Vian Ossick,
Sofia Pinheiro,
Augusto Etchegaray
Publication year - 2020
Publication title -
indian journal of dental research/indian journal of dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 43
eISSN - 1998-3603
pISSN - 0970-9290
DOI - 10.4103/ijdr.ijdr_495_17
Subject(s) - autoimmunity , disease , periodontal disease , autoimmune disease , immunology , oral cavity , medicine , pathological , biology , pathology , dentistry
Currently, there is a growing interest in studying systemic conditions associated with periodontal disease such as autoimmune disorders. Periodontal disease is a destructive inflammatory disease of the dental supporting tissues. The microorganisms associated with periodontal disease constitute diverse species that can colonize the oral cavity and influence the emergence or evolution of autoimmunity, characterized by a breakdown in the mechanisms of tolerance to self-antigens. Here, we reviewed and discussed a possible correlation between periodontal disease and autoimmunity, placing periodontal-pathogenic microorganisms as orchestrators of these pathological conditions.