Open AccessCorrelation of buccal micronucleus with disease activity score using buccal micronucleus cytome analysis (BMCA) in systemic lupus erythematosus
Author(s) -
Khalil Ibrahim Assiri,
Mohammad Shahul Hameed,
Ali Azhar Dawasaz,
Eman Saeed Alamoudi,
Alhussain Asiri,
Hitesh Vij,
Muhammed Ajmal
Publication year - 2020
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/ijd.ijd_620_18
Subject(s) - medicine , buccal administration , micronucleus , buccal swab , micronucleus test , gastroenterology , lupus erythematosus , colchicine , population , biomarker , systemic disease , disease , systemic lupus erythematosus , pathology , immunology , toxicity , antibody , dentistry , biochemistry , chemistry , genetics , environmental health , biology
A disease activity score obtained by using systemic lupus erythematosus disease activity index (SLEDAI) has traditionally been a reliable method to assess the SLE status of patients. More recently, a buccal micronucleus cytome assay (BMCA) has been developed for use as a biomarker of DNA damage in patients with SLE. There has been a very limited number of studies pertaining to the oral lesions in Arab population suffering from SLE in Asir region. Hence, it became utmost important to study epidemiological data of oral mucosal lesions in SLE patients. Distribution of oral lesions in SLE patients could also be helpful in better management of oral complications.