Propionibacterium acnes and the Th1/Th17 Axis, implications in acne pathogenesis and treatment | Zendy

Gunjan Verma | Zendy; Kabir Sardana | Zendy

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Propionibacterium acnes and the Th1/Th17 Axis, implications in acne pathogenesis and treatment

Author(s) -

Gunjan Verma,

Kabir Sardana

Publication year - 2017

Publication title -

indian journal of dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.395

H-Index - 36

eISSN - 1998-3611

pISSN - 0019-5154

DOI - 10.4103/ijd.ijd_483_16

Subject(s) - propionibacterium acnes , acne , medicine , pathogenesis , isotretinoin , immune system , cancer research , transforming growth factor , immunology , vitamin d and neurology , interleukin 23 , interleukin 17 , dermatology

Acne vulgaris is one of the most commonly seen conditions and the immunological link is a topic of active research. Recently, the Th17 pathway has been found to play a pivotal role in acne. The adaptive immune response toward Propionibacterium acnes leads to activation of Th17 axis. Consequently, the Th17 cytokines (IL-17, IL-1 β, IL-6, and tumor growth factor, in turn, activate the various pathogenic steps in acne. Drugs such as Vitamin D3 and isotretinoin which target the Th17 pathway may offer an additional pathway for their therapeutic response.

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