Open AccessVitamin D Receptor gene polymorphisms taq-1 and cdx-1 in female pattern hair loss
Author(s) -
Iman Seleit,
Ola Ahmed Bakry,
Eman Badr,
Mai S. Mabrouk
Publication year - 2020
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/ijd.ijd_482_18
Subject(s) - hair loss , calcitriol receptor , genotype , medicine , allele , dermatology , genetics , gene , vitamin d and neurology , biology
Female pattern hair loss (FPHL) is an important cause of hair loss in adult women and has a major impact on patient's quality of life. It evolves from the progressive miniaturization of follicles that leads to a subsequent decrease of hair density, leading to non-scarring diffuse alopecia, with characteristic clinical, dermoscopic, and histological patterns. Vitamin D receptor (VDR) is expressed in follicular keratinocytes and dermal papilla cells and is shown to have important role in hair growth and regulation of hair cycle. VDR polymorphism was not extensively investigated in hair disorders including FPHL.