Open AccessInvestigation of immunovascular polymorphisms and intersections in psoriasis
Author(s) -
Buket Er Urganci,
İbrahim Açıkbaş,
Fedorova Er
Publication year - 2019
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/ijd.ijd_422_18
Subject(s) - psoriasis , pathogenesis , single nucleotide polymorphism , medicine , haplotype , immunology , vascular endothelial growth factor , genetic predisposition , serotonergic , disease , allele , cancer research , biology , genetics , pathology , gene , genotype , vegf receptors , serotonin , receptor
Psoriasis is a chronic, inflammatory skin disease. The etiology of the disease is unknown. It is a polygenic and multifactorial disease, which interacts with genetic and environmental factors. Genetic factors (polymorphism/mutation) can alter the immune system and normal physiologically functioning keratinocytes to pathological or predisposition levels.