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Antimelanocyte antibodies: A possible role in patients with vitiligo
Author(s) -
Mohammad A. Gaballah,
MahaA El-Gayyar,
ManalE Helmy,
EmanR Amer,
M el-Saied
Publication year - 2020
Publication title -
indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/ijd.ijd_344_18
Subject(s) - vitiligo , medicine , pathogenesis , autoantibody , immunology , anti nuclear antibody , antibody , disease , alopecia areata , dermatology , pathology
Vitiligo is an acquired depigmenting skin disorder with multifactorial pathogenesis including genetic, autoimmune, and neuronal factors. Both humoral- and cell-mediated immunities are supposed to have a role in the pathogenesis of vitiligo. Patients with vitiligo have an increased concentration of circulating autoantibodies that are specific to melanocyte cytoplasm and surface antigens that related to the extent of the disease.

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