Open AccessPeroxisome proliferator-activated receptor-γ gene polymorphism in psoriasis and its relation to obesity, metabolic syndrome, and narrowband ultraviolet B response: A case–control study in Egyptian patients
Author(s) -
Iman Seleit,
Ola Ahmed Bakry,
Eman Masoud Abd El Gayed,
Mai Medhat Mohamed Ghanem
Publication year - 2019
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/ijd.ijd_114_18
Subject(s) - psoriasis , medicine , psoriasis area and severity index , body mass index , metabolic syndrome , etiology , gene polymorphism , allele , gastroenterology , obesity , endocrinology , restriction fragment length polymorphism , immunology , genotype , genetics , gene , biology
Psoriasis is a common dermatologic disease with multifactorial etiology in which genetic factors play a major role. Peroxisome proliferator-activated receptor (PPAR)-γ is expressed in keratinocytes and is known to affect cell maturation and differentiation in addition to its role in inflammation.